Transcription within Condensed Chromatin: Steric Hindrance Facilitates Elongation
نویسندگان
چکیده
منابع مشابه
Transcription within condensed chromatin: Steric hindrance facilitates elongation.
During eukaryotic transcription, RNA-polymerase activity generates torsional stress in DNA, having a negative impact on the elongation process. Using our previous studies of chromatin fiber structure and conformational transitions, we suggest that this torsional stress can be alleviated, thanks to a tradeoff between the fiber twist and nucleosome conformational transitions into an activated sta...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.10.054